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GlycoFlux™ Human SIGLEC12 Overexpression HEK293 Cell Line

CAT#: GLJF-0925-JF858

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC12 overexpression HEK293 cell line is a stable cell line expressing SIGLEC12, an immunoglobulin receptor with ITIM and SLAM-like motifs that regulate immune signaling via SHP1/2 recruitment. Located in a SIGLEC gene cluster on 19q13.4, it undergoes alternative splicing to generate multiple isoforms. This model provides a versatile platform for studying inhibitory immune signaling, glycan-mediated receptor activity, and glycosylation-driven regulation.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
FBS & Penicillin/Streptomycin & Proline & DMEM
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC12
Full Name
Sialic Acid Binding Ig Like Lectin 12
Alternative Name
S2V, SLG, SIGLECL1, Siglec-XII, Sialic Acid Binding Ig Like Lectin
Location
19q13.41
Gene ID
89858
Summary
This gene encodes a member of the SIGLEC3-like subfamily, characterized by extracellular V-set and C2-set immunoglobulin-like domains, and cytoplasmic motifs ITIM and SLAM-like. Tyrosine phosphorylation of the protein recruits SHP1 and SHP2, functioning as an inhibitory receptor in macrophage signaling regulation. The gene is located on 19q13.4 and undergoes alternative splicing to produce multiple transcript variants.
For Research Use Only.
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