Recombinant Human C-type lectin domain containing 6a (CLEC6A) protein, NS0 cell line

Recombinant Human C-type lectin domain containing 6a (CLEC6A) protein (NP_001007034.1) was expressed in NS0 cell line. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, IP.

Determined by its binding ability in a functional ELISA.

NS0 cell line

Human

>90%, determined by SDS-PAGE and HPLC

Unconjugated

CLEC6A

C-type lectin domain containing 6a

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene.

CLEC4N; CLECSF10; Dectin-2; hDECTIN-2; CLEC6A; C-type lectin domain containing 6a