Knowledge Center
A comprehensive hub for technical insights, formulation strategies, and application guides in lipid-based drug delivery.
About the Knowledge Center
Welcome to our Knowledge Center, your premier destination for expert insights into lipid-based drug delivery systems. This hub is designed to support scientists and researchers with in-depth articles, technical guides, and the latest advancements in the field. Whether you are looking for formulation strategies, manufacturing solutions, or novel application data, our continuously updated library provides the critical information needed to accelerate your research.
LNP & Nucleic Acid
Formulation strategies for mRNA, siRNA, and gene editing payloads.
Optimizing LNP Molar Ratios for Transfection Efficiency
Discover how the stoichiometry of ionizable lipids, DSPC, cholesterol, and PEG-lipids dictates LNP structure and gene silencing potency.
Read ArticleScalability Challenges in mRNA-LNP Manufacturing
Analyzing the critical transition from microfluidic mixing in the lab to large-scale impingement jet mixing for clinical production.
Read ArticleBeyond mRNA: Applications of LNPs in CRISPR/Cas9 Gene Editing Systems
A deep dive into co-encapsulation strategies for Cas9 mRNA and sgRNA to achieve efficient in vivo genome editing.
Read ArticleEvolution of Cationic Lipids: From DOTAP to Next-Gen Ionizable Lipids
Tracing the chemical evolution of lipid headgroups and tails to minimize toxicity and maximize endosomal escape.
Read ArticleLNP Storage Stability: Lyophilization vs. Liquid Preservation Strategies
Comparing cryoprotectants and buffer systems to maintain particle integrity and payload efficacy during cold chain storage.
Read ArticleModulating LNP Biodistribution: Strategies to Overcome Liver Accumulation
Exploring surface charge modification and selective organ targeting (SORT) lipids to reach lungs, spleen, and beyond.
Read ArticleTargeting & Functionalization
Active targeting mechanisms, conjugation chemistry, and responsive systems.
Active vs. Passive Targeting (EPR): A Guide to Tumor Drug Delivery
Understanding the limitations of the EPR effect and when to implement active ligand targeting for superior therapeutic indices.
Read ArticleImmunoliposomes: Comparing Pre-insertion vs. Post-insertion Techniques
A technical comparison of coupling antibodies to pre-formed liposomes versus incorporating lipid-conjugated antibodies during formation.
Read ArticleCrossing the BBB: Advances in Transferrin and Peptide-Modified Liposomes
Reviewing the latest strategies to hijack receptor-mediated transcytosis pathways for effective brain drug delivery.
Read ArticleSmart Delivery: pH-Responsive Liposomes in the Tumor Microenvironment
Designing fusogenic lipids that destabilize in acidic endosomes to trigger rapid cytoplasmic payload release.
Read ArticleThermosensitive Liposomes combined with HIFU: Principles and Clinical Applications
How DPPC-based formulations work synergistically with High-Intensity Focused Ultrasound for localized hyperthermia-triggered release.
Read ArticleAptamer-Modified Liposomes: A Stable and Cost-Effective Alternative to Antibodies
Evaluating the advantages of oligonucleotide aptamers in terms of production cost, stability, and low immunogenicity compared to mAbs.
Read ArticleTransdermal & Special Formulations
Novel delivery routes and solubility enhancement techniques.
Ethosomes vs. Transfersomes: A Guide to Enhanced Dermal Delivery
Analyzing how ethanol content versus edge activators influences the elasticity and skin penetration depth of vesicular systems.
Read ArticleStrategies for Encapsulating Poorly Water-Soluble Small Molecules in Liposomes
Techniques for maximizing drug-to-lipid ratios for hydrophobic compounds, including remote loading and solvent injection methods.
Read ArticleNeed Specific Formulation Advice?
Our scientists have decades of experience in liposome engineering. Whether you are troubleshooting an LNP formulation or designing a novel targeting ligand, we can help.
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