Knowledge Center
A comprehensive hub for technical insights, formulation strategies, and application guides in lipid-based drug delivery.
About the Knowledge Center
Welcome to our Knowledge Center, your premier destination for expert insights into lipid-based drug delivery systems. This hub is designed to support scientists and researchers with in-depth articles, technical guides, and the latest advancements in the field. Whether you are looking for formulation strategies, manufacturing solutions, or novel application data, our continuously updated library provides the critical information needed to accelerate your research.
LNP & Nucleic Acid
Formulation strategies for mRNA, siRNA, and gene editing payloads.
Golden Rules of LNP Formulation: Impact of Molar Ratios
Discover how the stoichiometry of ionizable lipids, DSPC, cholesterol, and PEG-lipids dictates LNP structure and gene silencing potency.
Read ArticleScalability Challenges in mRNA-LNP Manufacturing
Analyzing the critical transition from microfluidic mixing in the lab to large-scale impingement jet mixing for clinical production.
Read ArticleApplications of LNPs in CRISPR/Cas9 Systems
A deep dive into co-encapsulation strategies for Cas9 mRNA and sgRNA to achieve efficient in vivo genome editing.
Read ArticleEvolution from DOTAP to Next-Gen Ionizable Lipids
Tracing the chemical evolution of lipid headgroups and tails to minimize toxicity and maximize endosomal escape.
Read ArticleLyophilization vs. Liquid Preservation Strategies
Comparing cryoprotectants and buffer systems to maintain particle integrity and payload efficacy during cold chain storage.
Read ArticleStrategies to Overcome Liver Accumulation
Exploring surface charge modification and selective organ targeting (SORT) lipids to reach lungs, spleen, and beyond.
Read ArticleTargeting & Functionalization
Active targeting mechanisms, conjugation chemistry, and responsive systems.
Active vs. Passive Targeting (EPR): A Comprehensive Guide
Understanding the limitations of the EPR effect and when to implement active ligand targeting for superior therapeutic indices.
Read ArticleImmunoliposomes: Pre-insertion vs. Post-insertion Techniques
A technical comparison of coupling antibodies to pre-formed liposomes versus incorporating lipid-conjugated antibodies during formation.
Read ArticleCrossing the BBB with Modified Liposomes
Reviewing the latest strategies to hijack receptor-mediated transcytosis pathways for effective brain drug delivery.
Read ArticleTrigger Mechanisms of pH-Responsive Liposomes
Designing fusogenic lipids that destabilize in acidic endosomes to trigger rapid cytoplasmic payload release.
Read ArticleThermosensitive Liposomes combined with HIFU
How DPPC-based formulations work synergistically with High-Intensity Focused Ultrasound for localized hyperthermia-triggered release.
Read ArticleAptamer-Modified Liposomes: An Alternative to Antibodies
Evaluating the advantages of oligonucleotide aptamers in terms of production cost, stability, and low immunogenicity compared to mAbs.
Read ArticleTransdermal & Special Formulations
Novel delivery routes and solubility enhancement techniques.
Ethosomes vs. Transfersomes: A Comparative Study
Analyzing how ethanol content versus edge activators influences the elasticity and skin penetration depth of vesicular systems.
Read ArticleEncapsulating Poorly Water-Soluble Small Molecules
Techniques for maximizing drug-to-lipid ratios for hydrophobic compounds, including remote loading and solvent injection methods.
Read ArticleMultivesicular Liposomes (MVL): The Architecture of Sustained Release
Exploring the unique honeycomb-like structure of MVLs and how they provide prolonged drug release compared to conventional unilamellar liposomes.
Read ArticleMechanisms of Liposomal Adjuvants in Enhancing Vaccine Immune Response
Understanding how antigen-encapsulating liposomes interact with antigen-presenting cells to boost humoral and cellular immunity.
Read ArticleProtecting Enzymatic Activity: Liposomal Encapsulation Strategies for Enzymes
Strategies to preserve the catalytic activity of fragile enzymes during the encapsulation process and protect them from proteolytic degradation in vivo.
Read ArticleCharacterization & QC
Analytical methods for quality control, stability testing, and regulatory compliance.
Cryo-TEM vs. DLS: Interpreting Discrepancies in Liposome Particle Size Data
A critical look at why hydrodynamic diameter measured by DLS often differs from the direct visualization provided by Cryo-TEM.
Read ArticleValidating In Vitro Release Methods: Dialysis vs. Sample Separation Techniques
Comparing the accuracy and reproducibility of dialysis bag methods versus sample-and-separate techniques for drug release profiling.
Read ArticlePredicting Long-Term Stability of Liposomal Suspensions using Zeta Potential
How surface charge measurements can serve as an early indicator of aggregation risk and shelf-life stability.
Read ArticleTroubleshooting Low Liposome Encapsulation Efficiency
Identifying common pitfalls in drug loading, from lipid transition temperatures to pH gradients and buffer compatibility.
Read ArticleApplication of Multi-omics Analysis in Liposome Toxicology Assessment
Utilizing advanced proteomics and metabolomics to understand cellular responses and potential toxicity of novel lipid formulations.
Read ArticleDIY Guides & Materials
Practical protocols, material selection, and hands-on preparation guides.
The Ultimate Guide to Liposome Preparation: Thin-Film Hydration vs. Ethanol Injection
A step-by-step comparison of the two most common lab-scale liposome preparation methods, helping you choose the right one for your payload.
Read ArticleFluorescent Liposomes for Cellular Uptake: Labeling, Controls, and Troubleshooting
Best practices for incorporating fluorescent dyes into lipid bilayers for tracking cellular internalization and trafficking.
Read ArticleHow to Design Stealth Liposomes for Long Circulation: PEGylation Principles & Formulation Strategies
Understanding the physics of PEGylation, including density regimes and chain length, to effectively evade the reticuloendothelial system.
Read ArticleHomemade vs. Commercial Kits: Why Standardization Matters in Liposome Research
Evaluating the trade-offs between cost-effective homemade liposomes and the reproducibility offered by commercial preparation kits.
Read ArticleNeed Specific Formulation Advice?
Our scientists have decades of experience in liposome engineering. Whether you are troubleshooting an LNP formulation or designing a novel targeting ligand, we can help.
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