GlycoErase™ SIGLEC9 Knockout A549 Cell Line

GlycoErase™ SIGLEC9 knockout A549 cell line is a human lung epithelial cancer model in which SIGLEC9 expression has been eliminated. SIGLEC9 is predicted to exhibit monosaccharide and sialic acid binding activity, contribute to cell adhesion, and act in the negative regulation of inflammatory responses and phagocytosis. Localized on the external side of the plasma membrane, SIGLEC9 serves as an inhibitory receptor in immune signaling. The absence of SIGLEC9 in the A549 background provides a practical model to study inflammation control, immune suppression, and adhesion-related biology, and supports applications in immunology, anti-inflammatory drug development, and host defense research.

KO Cell Lines

Human

Epithelial-like, adherent

1:3~1:6

A549

Non-small cell lung cancer

Lung

Non-small cell lung cancer

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

F-12K & FBS & Penicillin/Streptomycin

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC9

Sialic Acid Binding Ig Like Lectin 9

CD329, CDw329, FOAP-9, siglec-9, OBBP-LIKE, Sialic Acid Binding Ig Like Lectin

19q13.3-q13.4

Predicted to enable monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis, engulfment. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane.