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GlycoErase™ UGGT1 Knockout Human Malignant Melanoma Cell A375

CAT#: GLJF-0525-JF1254

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Overview Specification Target Information Related Products
Overview
Description
UGGT1 knockout A375 cells, deficient in UGGT1 protein crucial for protein quality control in the ER, enable the study of impaired protein folding's effects on melanoma, impacting the unfolded protein response and melanoma functions.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:3~1:4
Cell Line
A375
Primary Disease
Melanoma
Lineage
Skin
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
UGGT1
Full Name
UDP-glucose glycoprotein glucosyltransferase 1
Alternative Name
HUGT1, UGCGL1
Location
2q14.3
Gene ID
56886
Summary
Quality control maestro of the endoplasmic reticulum, selectively reglucosylating unfolded glycoproteins to ensure proper protein folding and transport.
For Research Use Only.
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