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GlycoFlux™ Human SIGLEC14 Overexpression Glycoengineered Cell

CAT#: GLJF-0925-JF127

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC14 overexpression glycoengineered cell is a stable cell line that constitutively overexpresses SIGLEC14, an activating, DAP12-coupled receptor that pairs functionally with inhibitory SIGLEC5. The system enables side-by-side assays of activating vs. inhibitory signaling on defined glycan landscapes, modeling host-pathogen responses, and identifying glycomimetic modulators that rebalance the SIGLEC14/5 axis.
Product Type
Overexpression Cell Lines
Cell Line
As requested by the client.
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC14
Full Name
Sialic Acid Binding Ig Like Lectin 14
Alternative Name
Sialic Acid Binding Ig Like Lectin
Location
19q13.41
Gene ID
100049587
Summary
Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in ficolin-1-rich granule membrane and tertiary granule membrane. Predicted to be active in plasma membrane.
For Research Use Only.
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