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L-Lysine-2HCl, 4,4,5,5-D4 for SILAC (CAT#: GLJF-0225-HX26)

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Product Description L-Lysine-2HCl, 4,4,5,5-D4 is a deuterium-labeled form of the essential amino acid lysine, specifically designed for use in stable isotope labeling by amino acids in cell culture (SILAC) experiments. In this compound, four hydrogen atoms at positions 4 and 5 on the lysine molecule are replaced with deuterium, a stable isotope of hydrogen. This substitution increases the molecular weight of lysine without altering its chemical properties, allowing it to be incorporated seamlessly into proteins during cell growth. In SILAC applications, cells are cultured in media containing this labeled lysine, leading to the synthesis of proteins with deuterium-labeled lysine residues. When analyzed by mass spectrometry, the labeled proteins can be distinguished from unlabeled counterparts based on the mass difference introduced by deuterium. This enables precise quantification and comparative analysis of protein expression, turnover, and post-translational modifications in different biological samples, making L-Lysine-2HCl, 4,4,5,5-D4 a valuable tool in proteomics research.
CAS 203633-22-1
Synonyms 203633-22-1; L-Lysine-2HCl, 4,4,5,5-D4; L-Lysine-d4 (dihydrochloride); (2S)-2,6-Diamino-4,4,5,5-tetradeuteriohexanoic acid;dihydrochloride; L-Lysine-4,4,5,5-D4, dihydrochlorid
Formula C6H16C12N2O2
MW 223.13
InChI InChI=1S/C6H14N2O2.2ClH/c7-4-2-1-3-5(8)6(9)10;;/h5H,1-4,7-8H2,(H,9,10);2*1H/t5-;;/m0../s1/i1D2,2D2;
InChI Key JBBURJFZIMRPCZ-RGTYBCOQSA-N
Purity Min. 95%
Identity Conforms to structure
Storage Store at 2-8°C for long term storage.
Application L-Lysine-2HCl, 4,4,5,5-D4 for SILAC is a stable isotope-labeled form of the essential amino acid L-lysine. SILAC using this deuterated lysine is widely employed to study changes in protein expression, post-translational modifications, and protein-protein interactions in various biological contexts. The use of deuterium labels offers a specific mass shift suitable for mass spectrometry analysis and can be advantageous in certain experimental designs.
For Research Use Only.
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