GlycoErase™ SIGLEC11 Knockout HEK293 Cell Line

GlycoErase™ SIGLEC11 knockout HEK293 cell line is a HEK293 cell line where SIGLEC11 expression has been deleted. SIGLEC11 is a sialic acid-binding receptor with conserved Ig-like domains, known to mediate anti-inflammatory and immunosuppressive signaling, and multiple isoforms exist. The knockout of SIGLEC11 in the HEK293 background provides a relevant system for examining immune suppression pathways and inflammatory control, and supports applications in therapeutic antibody validation, molecular biology, and translational research.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & Proline & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC11

Sialic Acid Binding Ig Like Lectin 11

Sialic Acid Binding Ig Like Lectin

19q13.33

This gene encodes a sialic acid-binding immunoglobulin-like lectin, involved in anti-inflammatory and immunosuppressive signaling. Several isoforms of this protein are produced through alternative splicing.