GlycoErase™ SIGLEC6 Knockout Jurkat Cell Line (CAT#: GLJF-0825-JF897)

Description	GlycoErase™ SIGLEC6 knockout Jurkat cell line is a Jurkat T lymphocyte line where SIGLEC6 expression has been eliminated. SIGLEC6 is a transmembrane receptor that recognizes sialyl-TN glycans and leptin, with expression upregulated in placental tissue during preeclampsia. This knockout Jurkat model supports research into glycan-protein interactions, metabolic signaling in immune contexts, and immune regulation, with applications in cytokine modulation studies, immune-metabolic research, and biomarker discovery.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Suspension-growing
Passage Ratio	1:3~1:5
Cell Line	Jurkat cell line
Primary Disease	T-cell acute lymphoblastic leukemia (T-ALL)
Lineage	T Lymphocyte
Lineage Subtype	T-cell acute lymphoblastic leukemia (T-ALL)

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SIGLEC6
Full Name	Sialic Acid Binding Ig Like Lectin 6
Alternative Name	CD327, CD33L, OBBP1, CD33L1, CD33L2, CDW327, Sialic Acid Binding Ig Like Lectin
Location	19q13.41
Gene ID	946
Summary	This gene encodes a member of the SIGLEC family of proteins. The encoded transmembrane receptor specifically binds sialyl-TN glycans and leptin. Its expression in the placenta is elevated in preeclampsia.