GlycoErase™ SIGLEC6 Knockout Jurkat Cell Line

GlycoErase™ SIGLEC6 knockout Jurkat cell line is a Jurkat T lymphocyte line where SIGLEC6 expression has been eliminated. SIGLEC6 is a transmembrane receptor that recognizes sialyl-TN glycans and leptin, with expression upregulated in placental tissue during preeclampsia. This knockout Jurkat model supports research into glycan-protein interactions, metabolic signaling in immune contexts, and immune regulation, with applications in cytokine modulation studies, immune-metabolic research, and biomarker discovery.

KO Cell Lines

Human

Suspension-growing

1:3~1:5

Jurkat cell line

T-cell acute lymphoblastic leukemia (T-ALL)

T Lymphocyte

T-cell acute lymphoblastic leukemia (T-ALL)

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC6

Sialic Acid Binding Ig Like Lectin 6

CD327, CD33L, OBBP1, CD33L1, CD33L2, CDW327, Sialic Acid Binding Ig Like Lectin

19q13.41

This gene encodes a member of the SIGLEC family of proteins. The encoded transmembrane receptor specifically binds sialyl-TN glycans and leptin. Its expression in the placenta is elevated in preeclampsia.