GlycoErase™ SIGLEC9 Knockout HepG2 Cell Line

GlycoErase™ SIGLEC9 knockout HepG2 cell line is a HepG2 model without SIGLEC9 expression. SIGLEC9 is predicted to bind sialic acids and monosaccharides, contribute to cell adhesion, and negatively regulate inflammatory responses and phagocytosis. Localized to the plasma membrane, SIGLEC9 functions as an inhibitory receptor. The knockout in HepG2 offers a liver-relevant model for investigating immune suppression, inflammation control, and adhesion processes, supporting applications in drug metabolism, hepatology, and therapeutic development.

KO Cell Lines

Human

Epithelial-like, adherent

1:4~1:6

HepG2

Hepatoblastoma

Liver

Hepatoblastoma

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

DMEM & FBS & Glutamine

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

SIGLEC9

Sialic Acid Binding Ig Like Lectin 9

CD329, CDw329, FOAP-9, siglec-9, OBBP-LIKE, Sialic Acid Binding Ig Like Lectin

19q13.3-q13.4

This protein is predicted to have monosaccharide and sialic acid binding activities and to participate in cell adhesion. It is involved in the negative regulation of inflammatory responses and phagocytosis, and is predicted to be located on the external side of the plasma membrane.