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GlycoFlux™ Human SIGLEC10 Overexpression HepG2 Cell Line

CAT#: GLJF-0925-JF848

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human SIGLEC10 overexpression HepG2 cell line is a stable cell line engineered to express SIGLEC10, an ITIM-bearing immune lectin of the immunoglobulin superfamily. It is broadly expressed in innate immunity but not in B-cells except for SIGLEC6. This system allows interrogation of inhibitory signaling, glycan recognition in hepatocyte-like cells, and the functional impact of glycosylation on innate immune checkpoint pathways.
Product Type
Overexpression Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
SIGLEC10
Full Name
Sialic Acid Binding Ig Like Lectin 10
Alternative Name
SLG2, PRO940, SIGLEC-10, Sialic Acid Binding Ig Like Lectin
Location
19q13.41
Gene ID
89790
Summary
SIGLECs are members of the immunoglobulin superfamily and are expressed primarily on cells of the innate immune system, except for SIGLEC6, which is expressed on B-cells. Most SIGLECs contain one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIMs).
For Research Use Only.
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