Ionizable lipid YSK05

YSK05 is an ionizable amino lipid specifically engineered for constructing lipid nanoparticles (LNPs) that efficiently encapsulate and deliver therapeutic nucleic acids, primarily siRNA. YSK05-containing LNPs have been successfully administered intravenously to mice, demonstrating effective gene silencing in hepatocytes (liver cells). This lipid's design is based on pH-sensitivity, facilitating the necessary endosomal escape of the payload and making it a key compound for developing liver-targeted siRNA therapeutics.

1318793-78-0

1-Methyl-4,4-bis[(9Z,12Z)-octadeca-9,12-dienoxy]piperidine; YSK 05; 1-Methyl-4,4-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)piperidine

C₄₂H₇₇NO₂

628.1

InChI=1S/C42H77NO2/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-40-44-42(36-38-43(3)39-37-42)45-41-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h12-15,18-21H,4-11,16-17,22-41H2,1-3H3/b14-12-,15-13-,20-18-,21-19-

KURBRAZBXURPCJ-QYCRHRGJSA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.