Recombinant Varicella-zoster virus (VZV) (strain Oka vaccine) Envelope glycoprotein I (gI) (21-354 aa), E. coli (CAT#: GPX04-443J)

Product Overview	Recombinant Varicella-zoster virus (VZV) (strain Oka vaccine) Envelope glycoprotein I (21-354 aa) was expressed in E. coli with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	E. coli
Species	Varicella-zoster virus (VZV) (strain Oka vaccine)
Fragment	21-354 aa
Sequence	LIFKGDHVSLQVNSSLTSILIPMQNDNYTEIKGQLVFIGEQLPTGTNYSGTLELLYADTV AFCFRSVQVIRYDGCPRIRTSAFISCRYKHSWHYGNSTDRISTEPDAGVMLKITKPGIND AGVYVLLVRLDHSRSTDGFILGVNVYTAGSHHNIHGVIYTSPSLQNGYSTRALFQQARLC DLPATPKGSGTSLFQHMLDLRAGKSLEDNPWLHEDVVTTETKSVVKEGIENHVYPTDMST LPEKSLNDPPENLLIIIPIVASVMILTAMVIVIVISVKRRRIKKHPIYRPNTKTRRGIQN ATPESDVMLEAAIAQLATIREESPPHSVVNPFVK
Tag	His-tag or Tag free
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	gI
Full Name	Envelope glycoprotein I
Uniprot ID	Q77NN4
Background	In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US12, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.
Alternate Names	Envelope glycoprotein I