Recombinant Varicella-zoster virus (VZV) (strain Oka vaccine) Envelope glycoprotein I (gI) (21-354 aa), E. coli

Recombinant Varicella-zoster virus (VZV) (strain Oka vaccine) Envelope glycoprotein I (21-354 aa) was expressed in E. coli with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.

Determined by its binding ability in a functional ELISA.

Varicella-zoster virus (VZV) (strain Oka vaccine)

21-354 aa

LIFKGDHVSLQVNSSLTSILIPMQNDNYTEIKGQLVFIGEQLPTGTNYSGTLELLYADTV AFCFRSVQVIRYDGCPRIRTSAFISCRYKHSWHYGNSTDRISTEPDAGVMLKITKPGIND AGVYVLLVRLDHSRSTDGFILGVNVYTAGSHHNIHGVIYTSPSLQNGYSTRALFQQARLC DLPATPKGSGTSLFQHMLDLRAGKSLEDNPWLHEDVVTTETKSVVKEGIENHVYPTDMST LPEKSLNDPPENLLIIIPIVASVMILTAMVIVIVISVKRRRIKKHPIYRPNTKTRRGIQN ATPESDVMLEAAIAQLATIREESPPHSVVNPFVK

His-tag or Tag free

>90%, determined by SDS-PAGE.

Unconjugated

gI

Envelope glycoprotein I

In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US12, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.

Envelope glycoprotein I