Clodronate Liposome is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. When animals or cells are treated with Clodronate Liposome, phagocytic cells recognize the liposomes as invading foreign particles and proceed to remove the liposomes from the local tissue or serum via phagocytosis. The liposomes then release clodronate into the cytosol, resulting in cell death. Non-encapsulated clodronate cannot cross the cell membrane to initiate cell death.
Lipid Composition
L-alpha-Phosphatidylcholine, Cholesterol
Encapsulated Drug
Clodronate, Disodium Salt
Concentration
10mg/mL
Buffer
PBS, pH 7.4
Storage
Store in dark at +4°C and do not freeze
Size
1.5-2 µm
Quantity
5mL (available in lyophilized powder)
Dosage
Download
DataSheet
MSDS
FAQsPublished Data Customer ReviewsRelated Sections
How do Clodronate liposomes work?
Upon administration, Clodronate liposomes are recognized by phagocytic cells as foreign entities. These cells ingest the liposomes, which then release clodronate into the cytosol, leading to cell death.
Why use Clodronate liposomes over non-encapsulated clodronate?
Clodronate encapsulated within liposomes can cross cell membranes via phagocytosis, which is not feasible with non-encapsulated clodronate, ensuring targeted cell death.
What is the advantage of using Clodronate liposomes in research?
Clodronate liposomes offer a selective method to deplete phagocytic cells, facilitating studies on immune function and disease without affecting other cell types.
Are there any specific storage conditions for Clodronate liposomes?
Clodronate liposomes should be stored at controlled room temperatures and protected from prolonged exposure to light to maintain stability and efficacy.
Clodronate treatment decreases F4/80-positive cells in extraction sockets
The research suggests that the introduction of clodronate-loaded liposomes has a significant impact on the concentration of F4/80+ macrophages within the extraction sockets. This phenomenon highlights the macrophages' instrumental role in the process of bone remodeling and healing. The observed decrease in macrophage count due to the clodronate-loaded liposomes correlates with a subsequent shift in osteoclast activity, which directly influences the bone dynamics throughout the healing trajectory.
Michalski, M. N., et al. Clodronate-loaded liposome treatment has site-specific skeletal effects. Journal of Dental Research. 2019, 98(4): 459-467.
Efficient Delivery System
The clodronate liposomes provided by Creative Biolabs displayed remarkable delivery efficiency. Their stability and high efficacy in laboratory tests significantly improved the research outcomes.
Exceptional Cellular Penetration
Excellent product! The penetrative ability of the clodronate liposomes in cell culture experiments was impressive. It enhanced cell absorption rates, greatly increasing the reliability of experimental results.
Consistent Product Quality
Consistent and repeatable results were obtained each time the clodronate liposomes were used. Such consistency is crucial for long-term research projects.
User-Friendly Packaging Design
The packaging of this product is both practical and easy to handle. Easy access and usability significantly increased efficiency in lab work.
Outstanding Technical Support
Excellent technical support and customer service were experienced when using the clodronate liposomes. Any queries and issues were quickly addressed, enhancing confidence in their use.
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For Research Use Only. Not For Clinical Use