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GlycoFlux™ Human MAN2A1 Overexpression Glycoengineered Cell

CAT#: GLJF-0925-JF202

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Overview Specification Target Information Related Products
Overview
Description
GlycoFlux™ human MAN2A1 overexpression glycoengineered cell is a stable cell line that constitutively overexpresses MAN2A1, the Golgi mannosidase II that performs the final hydrolytic trim in the N-glycan maturation pathway. Elevated MAN2A1 accelerates conversion of hybrid/high-mannose to complex glycans, improving product consistency and enabling evaluation of how maturation state affects Fc effector function, receptor half-life, and pharmacokinetics.
Product Type
Overexpression Cell Lines
Cell Line
As requested by the client.
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
qPCR, Sanger Sequencing
Application
Mechanistic studies; Exploration of glycosylation and signaling pathways in cancer, metabolic, and immune-related diseases; Drug target validation and other functional assays.
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
MAN2A1
Compounds Targeting
1-Deoxymannojirimyci (Alpha Mannosidase Inhibitor)
Kifunensine (Mannosidase Inhibitor)
Swainsonine (Alpha Mannosidase Inhibitor)
Full Name
Mannosidase alpha class 2A member 1
Alternative Name
MANA2; MANII; GOLIM7
Location
5q21.3
Gene ID
4124
Summary
Golgi-localized glycosyl hydrolase that catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway.
For Research Use Only.
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