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Aptamers are a kind of short single-stranded DNA or RNA oligonucleotides screened from randomized nucleic acid libraries by systematic ligand evolution by exponential enrichment (SELEX). It can bind to target molecules by folding secondary and tertiary structures into specific three-dimensional spatial arrangements. Aptamer-modified liposomes are available from Creative Biolabs for application in biosensors, medical diagnostics, and targeted drug delivery.
Fig.1 Schematic representation of aptamer-modified liposome.
Aptamers are categorized into peptide aptamers and nucleic acid aptamers based on their composition. Peptide aptamers are made up of a short sequence of amino acids linked to a stable protein scaffold, whereas nucleic acid aptamers are short strands of RNA or DNA oligonucleotides. Creative Biolabs specializes in the research of aptamer-modified liposomes and provides a variety of aptamer options to ensure you find the best liposome modification for your research.
Aptamer | Efficacy |
AS1411 | Promoting the binding of liposomes to nucleolin receptors, which is overexpressed in tumor cells. |
EGFR aptamer | Promoting the binding of liposomes to EGFR, which is overexpressed in tumor cells. |
Apt1 | Promoting the binding of liposomes to CD44, a transmembrane glycoprotein that is overexpressed in solid tumors. |
LC09 | Promoting the binding of liposomes to osteosarcoma cells. |
A10 | Promoting the binding of liposomes to prostate-specific membrane antigen (PSMA), which is expressed in prostate cancer cells. |
xPSM-A9 | |
A15 | Promoting the specific binding of liposomes to CD133, a membrane protein highly expressed on the surface of prostate cancer cells. |
TSA14 | Promoting the specific binding of liposomes to Tubo cells, a clonal line established in vitro from BALB-neu T mice with overexpression of HER-2 receptor (HER2/erb-2). |
DAG-NX213 | Promoting the binding of liposomes to VEGF, which is overexpressed in tumor cells. |
NX 1838 | |
sgc8 | Promoting the binding of liposomes to leukemia CCRF-CEM cells. |
IL-4Ra | Promotion the binding of liposomes to IL-4Ra receptor, which is expressed in CT26 cancer cells |
With our expertise in covalent and non-covalent conjugation of aptamers, Creative Biolabs can provide customized aptamer-modified liposome services for your specific needs. In addition, Additionally, you can contact us to learn more about aptamer-drug conjugates and aptamer-modified nanoparticles. Trust us to leverage our knowledge and experience in aptamers to enhance the precision and efficiency of your research and development projects.