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GlycoErase™ ALG10 Knockout CHO-S Cell Line

CAT#: GLJF-0425-JF129

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Overview Specification Target Information Related Products
Overview
Description
To analyze early glucosylation steps, clarify the role of initial glucose in oligosaccharide transfer efficiency and glycoprotein folding, and ultimately optimize the performance of CHO-S cells in biopharmaceutical production, the ALG5 knockout CHO-S cell line is developed for relevant research.
Product Type
KO Cell Lines
Species
Hamster
Cell Morphology
Epithelial, suspension growth
Passage Ratio
1:3~1:5
Cell Line
CHO-S
Lineage
Chinese hamster ovary
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
CDMF & Glutamine & Penicillin/Streptomycin
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
ALG10
Full Name
ALG10 alpha-1,2-glucosyltransferase
Alternative Name
ALG10A, DIE2, FLJ14751
Location
12p11.1
Gene ID
84920
Summary
This gene encodes a membrane-associated protein that plays a critical role in N-linked glycosylation by adding the third glucose residue to the lipid-linked oligosaccharide precursor. Specifically, it transfers the terminal glucose molecule from dolichyl phosphate glucose (Dol-P-Glc) to the lipid-linked oligosaccharide Glc₂Man₉GlcNAc₂-PP-Dol. This step is essential for the proper assembly of the oligosaccharide precursor necessary for N-linked glycoprotein synthesis.
For Research Use Only.
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