At Creative Biolabs, we understand the immense potential of enzymes in therapeutic applications, from oncology and genetic disorders to diagnostics. However, harnessing this potential requires overcoming significant biological barriers, such as rapid degradation, immunogenicity, and lack of cellular uptake. Our liposome encapsulated enzyme development service provides a sophisticated and reliable solution, leveraging our deep expertise in lipid-based drug delivery systems to unlock new therapeutic possibilities for your research.
Liposome encapsulation technology directly confronts the principal challenge in enzyme therapeutics: in vivo instability. By enclosing therapeutic or diagnostic proteins within a robust lipid bilayer vesicle, we create a sophisticated nanocarrier. This vesicle serves as a critical protective barrier, effectively shielding the enzyme from proteolytic degradation and rapid immune clearance. This engineered protection not only extends the enzyme's functional half-life in circulation but also enables its targeted, controlled delivery to the specific site of action, thereby maximizing therapeutic efficacy and diagnostic precision.
Liposomal encapsulation is a critical strategy for advancing enzyme-based therapies. It provides a means to:
At Creative Biolabs, we offer a comprehensive suite of services designed to support every stage of your liposome-encapsulated enzyme project. Our capabilities span from custom liposome formulation to process optimization and detailed characterization. We are equipped to handle a wide variety of enzymes, from single proteins to complex multi-enzyme systems, and can provide a turnkey solution or collaborate on specific project stages to meet your unique needs.
| Disorder | Enzymes | Mechanism of Action |
|---|---|---|
| Lysosomal & Metabolic |
Arylsulphatase B pancreatic enzymes α-L-iduronidase β-galactosidase β-glucocerebrosidase Iduronate-2-sulfatase |
Replacing deficient or dysfunctional enzymes to restore metabolic balance. |
| Cancer | L-Asparaginase | Depletes asparagine to selectively target leukemia cells. |
|
Arginine deaminase Yaluronidase Kynureninase |
Degrades specific amino acids overexpressed in tumors. | |
| Urate oxidase | Reduces hyperuricemia by breaking down excess uric acid in cancers. | |
| Inflammation |
Catalase Superoxide dismutase |
Neutralizes reactive oxygen species to mitigate oxidative stress. |
| Cardiovascular |
Nattokinase Urokinase Streptokinase |
Dissolves fibrin clots to restore blood flow. |
| Digestive |
Amylases Lipases Proteases |
Breaks down dietary macronutrients to aid digestion. |
We pride ourselves on our proven track record of successfully developing stable, effective liposome-encapsulated enzyme formulations. In a recent project, our team successfully encapsulated an enzyme into liposomes with precisely controlled physical characteristics.
Creative Biolabs provides both liquid and freeze-dried (lyophilized) delivery solutions, offering you the flexibility to choose the format that best suits your downstream application and storage requirements.
| Step | Description | Starting Materials | Deliverables | Estimated Time |
|---|---|---|---|---|
| 1 | Feasibility Assessment | Enzyme sample |
Project Plan Proposed Timeline Detailed Quotation |
< 1 Week |
| 2 | Liposome Formulation & Encapsulation Optimization | Purified enzyme | Optimized liposome formulation | 2-4 Weeks |
| 3 | Characterization | Optimized formulation | Comprehensive data on particle size, zeta potential, and encapsulation efficiency | |
| 4 | Scale-Up & Process Validation (Optional) | Optimized formulation | A validated, scalable manufacturing process for the formulation | 1-2 Weeks |
| 5 | Final Product & COA | / | Product and COA | < 1 Week |
Our services are driving innovation across multiple fields, transforming how researchers approach therapeutic delivery and diagnostics.
Creative Biolabs is your trusted partner for advanced lipid-based drug delivery systems, including cutting-edge liposome-encapsulated enzyme development. Our comprehensive, end-to-end services are designed to accelerate your research, enhance therapeutic efficacy, and ensure the success of your project from concept to delivery. Contact our team for more information and to discuss your project
| Product Name | Description | Inquiry |
|---|---|---|
| Drug-loaded Liposomes | Pre-formulated liposomal drug for various disease research. | Inquiry |
| PEGylated Lipids | Lipids designed to increase liposome circulation time and stability. | Inquiry |
| Cholesterol (High Purity) | Essential lipid component for stable liposome formulation. | Inquiry |
| Advanced Liposome Preparation Kit | A comprehensive kit for easy liposome creation. | Inquiry |
For Research Use Only. Not For Clinical UseServices
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Creative Biolabs is a world-leading liposome provider with extensive experience in liposome preparation, custom formulation development, and characterization.
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