Biosynthesis of Glycoprotein
In recent years, much attention has been focused on glycoproteins for their extensive biological functions. The synthesis of glycoproteins is crucial to the research of glycoproteins. Creative Biolabs has been committed to glycoprotein research and established the advanced glycoprotein synthesis and detection platform. We are willing to provide high-quality glycoprotein synthesis services to customers all over the world.
Background of Glycoprotein
Glycoproteins play a vital role in the activities of organisms. They can serve as ligands for antibodies or lectins in mammals. It can also participate in processes such as signal, cell growth, cell interaction, and cell death. In addition, glycoproteins are also related to inflammation and cancer metastasis. There are multiple sugar chains of different structures in glycoproteins. Glycoproteins can be divided into two types according to the structure of the connection region between their sugar chains and the polypeptide backbone. These two types are O- linked glycoproteins and N- linked glycoproteins.
Biosynthesis of Glycoprotein
The biosynthesis of glycans is a delicate and complex process that requires the participation of multiple enzymes. Glycoprotein polypeptides are generally synthesized by the membrane-bound polysomes of the endoplasmic reticulum (ER). There are many differences in the biosynthesis of N- and O- linked oligosaccharides. However, in general, glycosylation in ER begins during polypeptide production or after synthesis. Then through the coated vesicles, glycoproteins are transported to the Golgi apparatus, where further processing and terminal glycosylation are completed. In the process of glycoproteins biosynthesis, specific glycosidase and Golgi glycosyltransferase are required.
Fig.1 Biosynthesis of N-glycosylated glycoproteins in eukaryotes. (Brockhausen, 2014)
Services in Creative Biolabs
The synthesis of glycoproteins has always been a hot spot. With the advancement of technology, more and more methods have been used for glycoprotein synthesis, including biosynthesis, chemical synthesis, enzymatic synthesis. Creative Biolabs is a leading provider of glycoprotein synthesis services. Our professional experts have professional knowledge and rich experience in glycoprotein synthesis and detection. We have an advanced glycoprotein synthesis and detection platform. We are pleased to choose the most suitable method for you. Our services related to glycoprotein biosynthesis include but are not limited to those listed below:
Features of Our Glycoprotein Biosynthesis Services
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Advanced and reliable platform
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Professional team specialized in glycoprotein biosynthesis
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Fast and effective synthesis technology
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Short synthesis cycle and good quality
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Reasonable price and high-quality after-sales service
Accurate and efficient synthesis is the basis for the success of the glycoprotein project. After decades of accumulation, Creative Biolabs is a leader in the field of glycoprotein research. Equipped with reliable technologies and professional scientists, we are confident to provide you with professional and high-quality custom glycoprotein synthesis services. Please feel free to contact us for more details.
Reference
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Brockhausen, I. Crossroads between bacterial and mammalian glycosyltransferases. Frontiers in immunology. 2014, 5: 492.
For Research Use Only.
Related Services:
- Chemical Synthesis of Glycoprotein
- Chemoenzymatic Synthesis of Glycoproteins
