Creative Biolabs is confident in offering the most relevant and reliable type I diabetes NHP models for global researchers. We provide all-round services from initial modeling, evaluation, to final result analysis and IND packaging. Our scientists have gained a great reputation for successfully accomplishing many challenging programs. Our well-characterized NHP type I disease models will definitely help to boost your drug development projects.
Definition and causes of type I diabetes
Type I diabetes (also known as insulin-dependent diabetes) is characterized by little or no insulin in vivo. Insulin is a hormone produced by the pancreas, which is required to facilitate cellular intake and consumption of sugar or glucose. Type I diabetes is basically caused by the destruction of pancreatic beta-cells. The occurrence of type I diabetes is very rare. According to the statistics, it accounts for only about 5% among all the diabetic patients. It often emerges during childhood or adolescence, sometimes also in adults.
Why we use non-human primates (NHPs) models to study type I diabetes?
From an evolutionary point of view, non-human primates (NHPs) are most similar to humans in physiology, anatomy, behavior, organ mechanisms, and immunology since they share approximate 95% genome homology. Given such high levels of similarity, NHP models are currently considered to play an indispensable part in to understand the mechanisms of diseases and drug discovery campaign.
Type I diabetes models provided by Creative Biolabs
It is reported that spontaneous type I diabetes occurs in an extremely low incidence in NHPs. Therefore, we utilize the well-established systemic administration of streptozotocin (STZ) strategy to induce type I diabetes. STZ is a naturally occurring chemical derived from the Streptomyces achromogenes. This diabetogenic drug is able to inhibit insulin secretion via the selective death of pancreatic beta-cells, thus resulting in typical type I diabetes disease status. A broad range of endpoint measurements are provided for elucidating the modeling outcomes as well as treatment efficacy:
With extensive experience and leading techniques, Creative Biolabs offers various Metabolic Disorder Models you may be interested in. Please feel free to contact us for more discussions.
| Metabolic Disorder Models | |
| Type I Diabetes Model | Type II Diabetes Model |
| Diet-Induced Obesity (DIO) Model | Primate Spontaneous Obesity Model |
| Primate Dyslipidemia Model | |
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