Creative Biolabs is confident in offering the most relevant and reliable type I diabetes NHP models for global researchers. We provide all-round services from initial modeling, evaluation, to final result analysis and IND packaging. Our scientists have gained a great reputation for successfully accomplishing many challenging programs. Our well-characterized NHP type I disease models will definitely help to boost your drug development projects.

Definition and causes of type I diabetes

Type I diabetes (also known as insulin-dependent diabetes) is characterized by little or no insulin in vivo. Insulin is a hormone produced by the pancreas, which is required to facilitate cellular intake and consumption of sugar or glucose. Type I diabetes is basically caused by the destruction of pancreatic beta-cells. The occurrence of type I diabetes is very rare. According to the statistics, it accounts for only about 5% among all the diabetic patients. It often emerges during childhood or adolescence, sometimes also in adults.

Type I Diabetes Model

Why we use non-human primates (NHPs) models to study type I diabetes?

From an evolutionary point of view, non-human primates (NHPs) are most similar to humans in physiology, anatomy, behavior, organ mechanisms, and immunology since they share approximate 95% genome homology. Given such high levels of similarity, NHP models are currently considered to play an indispensable part in to understand the mechanisms of diseases and drug discovery campaign.

Type I Diabetes Model

Type I diabetes models provided by Creative Biolabs

It is reported that spontaneous type I diabetes occurs in an extremely low incidence in NHPs. Therefore, we utilize the well-established systemic administration of streptozotocin (STZ) strategy to induce type I diabetes. STZ is a naturally occurring chemical derived from the Streptomyces achromogenes. This diabetogenic drug is able to inhibit insulin secretion via the selective death of pancreatic beta-cells, thus resulting in typical type I diabetes disease status. A broad range of endpoint measurements are provided for elucidating the modeling outcomes as well as treatment efficacy:

  • Body weight, height, body mass index (BMI)
  • Oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT)
  • Insulin tolerance test (ITT)
  • Graded glucose infusion (GGI)
  • Euglycemic clamping
  • GI-bypass and gastric emptying
  • Clinical chemistry metabolic profiling

Alternative cardiovascular and metabolic disorder models like type II diabetes and diet-induced obesity (DIO) is also available in Creative Biolabs. With extensive experience and leading techniques, we provide a variety of NHP disease models including neurological disease, renal disease, liver disease, urogenital disease, immune disease, etc. Other specific models can also be tailored upon request. Please feel free to contact us for further discussions.



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