As a pioneer and the undisputed global leader in antibody function analysis, Creative Biolabs is proud to offer our clients a series of Fab function analysis and characterization services with the best quality and most competitive price. Here, we are happy to introduce our professional service of GPCR-targeted functional assays with our diverse technologies.
Ion channels are a large family of membrane proteins that function by allowing ionic passage across cellular membranes. Present in all cell types, ion channels play critical roles in both physiology and disease by modulation of cellular functions such as electrical excitability, secretion, cell migration, and gene transcription. Mutations of single ion channel proteins have been demonstrated to be the cause of genetic diseases, collectively known as channelopathies. Due to the critical roles of ion channels in different biological processes, they represent an important class for therapeutics discovery. However, to date, small-molecule drugs, and peptide modulators dominate the ion channel-targeted drug discovery field. There exists a significant opportunity to target these channels with antibodies and other formats of biologics.
Fig.1 Antibody targeting Nav1.7. (Lee, 2014)
Antibodies display many advantages when compared to their small-molecule counterparts, including selectivity, bioavailability, and effector functions. Firstly, antibodies deliver superior specificity and selectivity targeting specific ion channel isoforms, thereby mitigating off-target effects and generating safer classes of drugs. Secondly, antibodies have limited central nervous system penetration and low variability in patient pharmacokinetics. Through different modifications, the half-life of antibodies can be extended to induce longer duration of action leading to reduced dosing. Thirdly, the potency and affinity of antibodies can be further enhanced and optimized by altering the Fc glycosylation status and using protein engineering methodologies.
Due to the above advantages, developing antibody-based therapeutics targeting ion channels can be of great importance for disease therapy. As a leading service provider of antibody development, Creative Biolabs offers professional anti-ion channel antibody discovery services via multiple state-of-the-art technologies.
Moreover, Creative Biolabs offers functional assays to help identify antibodies that modulate ion channel function. We use the accepted gold standard method for ion channel functional characterization, patch clamp electrophysiology, which allows real-time kinetic and pharmacological analysis of the effects of drug molecule candidates. We are capable of performing patch clamp assays using our cell lines that express specific ion channels. Particularly, we focus on a wide spectrum of ion channels that are implicated in human diseases, including but not limited to:
Creative Biolabs has accumulated years of experience in both ion-channel targeted antibody development and functional characterization to discover therapeutic antibodies targeting specific ion channels. With combined technology platforms and know-how, we are confident in providing first-class services with fast turnaround time and competitive prices. For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
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