Human FCGRT gene encodes the proteins called neonatal Fc receptor for IgG (FcRn), which plays a vital role in the maintenance of serum IgG levels. FcRn has been shown to interact with human serum albumin and IgG, and thus mediating the recycling and the protection of monomeric IgG and albumin from degradation. In recent years, FcRn-based therapies for immune as well as nonimmune disease has attracted great attention of researchers. To meet this end, Creative Biolabs goes all out to develop the humanized FCRGT knock-in mouse for you to discover and optimize the novel therapies/agents.
The Significance of FCRGT Function
Fc Fragment of IgG Receptor and Transporter (FCRGT), alternatively aliased as the neonatal Fc receptor for IgG (FcRn) and IgG Fc fragment receptor transporter alpha chain, encodes the receptor called IgG receptor FcRn large subunit p51 which binds the Fc region of monomeric immunoglobulins gamma. The FcRn belongs to the extensive and functionally divergent family of MHC molecules and mediates the selective uptake of IgG from milk and helps newborn animals to get passive immunity.
In contrast to classical MHC family members, FcRn has little diversity and is incapable of presenting Ags. On the contrary, FcRn regulates the serum half-lives of IgG and albumin, through its ability to bind these two proteins with high affinity at low pH. Moreover, FcRn plays a pivotal role in immunity at mucosal and systemic sites through its ability to affect the lifespan of IgG, as well as its participation in innate and adaptive immune responses. This protein also binds immunoglobulin G to keep the antibody from degradation. And the resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (by similarity).
Fig.1. The IgG–IC (IgG immune complexes) can bind to FcgR on the surface of DCs at neutral pH, initiating receptor-mediated endocytosis. (Pyzik, et al., 2015)
Applications of FcRn for Drug Delivery and Vaccine Development
Since angiogenesis plays a part in numerous pathological conditions, with KDR signaling involved in both tumor angiogenesis and diabetic retinopathy, the phosphorylation sites of KDR may be useful targets for the development of anti-angiogenic therapies to treat cancer and atherosclerosis. As to viral infection, FcRn may be responsible for shuttling infectious agents that either facilitate or prevent infection, relying on Ab-neutralizing abilities, site and pH of tissue.
Development of Humanized FCGRT Knock-In Mice
Animal models, especially mouse models, make it possible to simulate the biological processes in human body. Thus, these models allow scientists to study the mechanism of various signaling pathway and discover novel therapies against human disease. Creative Biolabs has developed a variety of world-class Magic™ “genetically humanized” mouse models by our unique transgenic knock-in method, including the humanized FCGRT knock-in mouse for your drug discovery studies. Our humanized FCGRT KI mice have naïve-like FCGRT expression and are well validated, ensuring high quality. Please feel free to contact us for more details.
Creative Biolabs also offers other various Humanized Mouse Models you may be interested in:
Reference
For Research Use Only.
