CRISPR/Cas9 Screening Service

Rely on Creative Biolabs' experienced team to carry out your program using optimized and validated CRISPR platform. Avoid the pitfalls of variability in cellular assays and benefit from the efficiency and accuracy of a dedicated facility.

CRISPR technology provides a precise and facile molecular mechanism for editing cells, tissue, and whole organisms, with wide-spread uses in experimental and applied systems. The system is derived from a prokaryotic adaptive immune system that provides DNA-encoded, RNA-mediated and sequence-specific protection against viruses. Through the use of a combination of crRNA and tracrRNA (the cas generated guiding components in native CRISPR) called sgRNA, Cas9 can be targeted to a specific genomic region. Once attached the enzyme can make a single-stranded ‘nick' or double-stranded ‘break' at a specified nucleotide. This region can be altered through the addition, subtraction or alteration of the sequence.

CRISPR has been exploited to develop potent tools for genome manipulation in animals, plants, and microorganisms. Creative Biolabs will help our clients to affect the next generation of drugs by accelerating the identification and validation of high-value targets, uncovering high-confidence biomarkers and developing differentiated breakthrough therapies with CRISPR technique. More than that, Creative Biolabs can also provide our clients advanced CRISPR service which can be used in various fields of therapeutics, xenotransplantation, and uses in crops, food organisms, and industrial microbes and so on.

The advantages of Creative Biolabs' CRISPR screening service:

• RNA-guided genomic DNA specific recognition needs no consideration of DNA methylation.
• The operation of gene editing can be highly efficient and flexible.
• Multiple genes can be edited at the same time.
• CRISPR lentivirus system can infection both division and non-division cells.
• CRISPR technique can be applied to any species.
• High-throughput

CRISPR screening service process:

CRISPR screening service including but not limited to:

• sgRNA Library Construction Service
• CRISPR/Cas9 Gene Knock-in Cell Lines Construction Service
• CRISPR/Cas9 Gene Knock-out Cell Lines Construction Service

CRISPR screening service is appropriate to:

• Identify and validate drug targets
• Find genes required for cell viability, drug sensitivity or resistance
• Identify targets or pathways for potential combination therapies

CRISPR screening service notes:

If you are interested in using our CRISPR screening service to support your target validation and identification program, please feel free to contact us for more details. A formal quote will be sent back to you as soon as possible.

For Research Use Only.