Immune checkpoint blockade therapies have emerged as a promising alternative for cancer treatment and have resulted in significantly successful outcome of cancer patients compared to conventional chemotherapy. Immune checkpoint receptors like CD28 has been of great interest in the study of cancer immunotherapy. CD28 and its ligands are part of what regulates T-cell activation by antigen presenting cells (APCs) and the immune system's ability to target cancerous cells. Creative Biolabs offers the best guarantee in the industry of genetically engineering models and has successfully launched an optimized Magic™ “humanized” animal platform to offer specialty humanized CD86 immune checkpoint knock-in mice for our clients all over the world.
CD86 Immune Checkpoint Pathway
The immune system should be able to generate an appropriate inflammatory response in order to effectively eliminate tumor cells. However, the fact that most of our immune cells contain a fail-safe mechanism to ensure they are not constantly activated is a double-edged sword. There are several markers found on both tumor cells and antigen presenting cells that can suppress or downregulate T cells once the corresponding ligand is bound.
CD86, also known as cluster of differentiation 86 and B7-2, is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. CD86 is the ligand for two different proteins on the T cell surface: CTLA-4 (for attenuation of regulation and cellular disassociation) and CD28 (for autoregulation and intercellular association). CD86 works in coordination with CD80 to prime T cells. It has been reported that CD86 is a potential prognostic factor in breast cancer and identify an immune-reactive subgroup of patients who may benefit from immune checkpoint blockade.
Fig. 1. Interactions between CD80, CD86, CD28 and CD152. (Sansom, et al., 2003)
Development of Humanized CD86 Immune Checkpoint Knock-In Mice
Immune checkpoint blockade has been investigated in clinical trials and showed great potential in various human cancer. Recently, immune checkpoint pathway has drawn a great deal of attention as a critical mechanism by which tumors can escape the natural anti-tumor immune response. With advanced technology, Creative Biolabs has successfully established a series of well-characterized Magic™ “humanized” animal models, which can provide you with humanized immune checkpoint knock-in mouse models including humanized CD86 knock-in mouse. Our scientists focused on knock-in mouse models are willing to assist you in the studies of anti-tumor immunotherapies. Please feel free to contact us for more detailed information.
Creative Biolabs also offers other Humanized Mouse Models you may be interested in:
Reference
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