Hs02, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ440)
Hs02 is a cationic amphiphilic antibacterial peptide derived from human proteins, and it is the membrane-active module of the core chimeric peptide Chim2. Hs02 exhibits broad-spectrum and potent antibacterial activity against various human pathogenic bacteria with the MIC for Staphylococcus aureus and Escherichia coli of as low as 2 μM, and the MBC is 2-4 μM. Hs02 primarily kills bacteria by disrupting the integrity of the bacterial cell membrane, and it has a relatively low selectivity for eukaryotic cell membranes. Hs02 induces the release of IL-12 but does not induce the release of IL-6, indicating its potential for pro-inflammatory or immune activation. Hs02 can be used in antibacterial and immunomodulatory research.
| Overview | |
|---|---|
| Synonyms | Hs02; Hs-02; Horseshoe crab peptide |
| Source | Synthetic |
| Sequence | Lys-Trp-Ala-Val-Arg-Ile-Ile-Arg-Lys-Phe-Ile-Lys-Gly-Phe-Ile-Ser-NH2 |
| Sequence Shortening | KWAVRIIRKFIKGFIS-NH2 |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; Cancer cells; Biofilm |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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