LEAP-2, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ3)

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LEAP-2 (Human liver expressed antimicrobial peptide-2) is a GHS-R1a antagonist, with an IC50 of 6.0 nM. LEAP-2 suppresses the orexigenic effect of ghrelin. LEAP-2 attenuates ghrelin-induced growth hormone (GH) release and reduces basal food intake. LEAP-2 exhibits antimicrobial activity against microbial model organisms. LEAP-2 can be used for the study of obesity and infection.

Overview
SynonymsHuman liver expressed antimicrobial peptide-2; LEAP-2; Liver-expressed antimicrobial peptide 2
SourceHuman
CAS1683582-94-6
Molecular FormulaC191H316N64O57S5
Molecular Weight4581.27
SequenceMet-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-Ala-Ser-Cys-Arg-Asp-Asp-Se r-Glu-Cys-Ile-Thr-Arg-Leu-Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu (Disulf ide bridge:Cys17-Cys28;Cys23-Cys33)
Sequence ShorteningMTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE (Disulfide bridge:Cys17-Cys28;C ys23-Cys33)
ActivityGram-positive bacteria; Gram-negative bacteria; Fungi; Virus; Cancer; GHSR; Iron; Human; Liver-expressed
Physical StatePowder
Purity>98%
StorageThe power can be stored at 4°C for 2 years or at -20°C for 3 years.

For Research Use Only.

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