PathSpecific™ B-RAF-V600E Assay Kit (Luminescent) (CAT#: ZL-0524-WR21)
| Overview | |
|---|---|
| Description | This kit is designed to measure B-Raf(V600E) kinase activity for screening and profiling applications. |
| Features | Ready-used for enzymatic activity assay. |
| Applications | Useful for examining enzyme kinetics and screening small molecule inhibitors for drug discovery in high throughput screening (HTS) applications. |
| Assay Measures | Luminescent |
| Research Areas | Kinase Drug Discovery; Signal Pathway; |
| Specification | |
|---|---|
| Size | 96 tests |
| Components | This kit includes enough purified recombinant B-Raf enzyme, B-Raf substrate, ATP, and kinase assay buffer for 100 enzyme tests. |
| Target | BRAF (V600E) |
| Target/Description | B-raf is a key protein involved in the MAP kinase signaling pathway, which regulates various cellular processes including cell growth, proliferation, and survival. Activation of B-raf by RAS leads to the phosphorylation of MEK1, initiating a cascade of signaling events that ultimately impact cell behavior. Given the crucial role of the MAP kinase pathway in melanoma development, targeting B-raf has been suggested as a potential strategy for treating this aggressive form of skin cancer. |
| Format | Luminescent Assay Kit |
| Storage | Store at the appropriate temperature as directed. |
| Handling | Please handle the product at appropriate storage condition once received. |
| Shipping | Dry ice |
| Regulatory Status | RUO |
For Research Use Only.
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