PathSpecific™ Human KDM4A Homogeneous Assay Kit (CAT#: ZL-0224-WR30)
| Overview | |
|---|---|
| Description | The kit is specifically designed for the quantification of KDM4A activity, making it useful for screening and profiling applications. |
| Features | Ready-used for enzymatic activity assay |
| Applications | Kit is used for compound screening and profiling. |
| Application Notes | Excellent for exploring the kinetics of enzymes, screening small molecule inhibitors, and HTS applications. |
| Research Areas | Kinase Drug Discovery; Signal Pathway; |
| Specification | |
|---|---|
| Size | 384 tests |
| Components | The kit is supplied with enough purified recombinant KDM4A (amino acids 1-350), substrate, primary antibody, assay, and detection buffer for 384 enzyme reactions. |
| Target | KDM4A |
| Target/Description | KDM4A, a key enzyme, is involved in the demethylation of various histone marks to regulate DNA damage response and transcription. Its overexpression is linked to various cancer types, including breast, gastric, ovarian, and liver cancers. In bladder cancer, high levels of KDM4A induce the epithelial-mesenchymal transition. Inhibitors targeting KDM4A are a promising area for potential cancer therapies and further research is needed for the development of efficient inhibitors. |
| Format | Supplied with a homogeneous assay kit |
| Storage | Store at the appropriate temperature as directed. |
| Handling | Please store the kit according to the storage instructions in the kit's manual upon receipt. |
| Shipping | Dry ice |
| Regulatory Status | RUO |
For Research Use Only.
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