PathSpecific™ VEGF-R2 Cell-based Phosphorylation Assay (CAT#: ZL-1122-LX341)
| Overview | |
|---|---|
| Short Name | VEGF-R2 Cell-based Phosphorylation Assay |
| Assay Overview | Creative Biolabs provides several specific target assays for the investigation of test articles focus the specific pathway. This assay is applied for compound screening and profiling in intact cells and will be customized according to the client's specific requirements. Please contact our scientists for assay development and custom-tailored screening details. |
| Assay type | Phosphorylation Assay |
| Assay Properties | |
|---|---|
| Short Description | For compound screening and profiling in intact cells |
| Substrates/Cell Line | HUE |
| Target Expression | Endogenous |
| Assay subtype | Cell-based Phosphorylation Assay |
| Assay format | 96-wells format |
| Target | |
|---|---|
| Target | KRD |
| Synonyms | VEGFR2; FLK1; VEGF-R2 |
| Target Species | Human |
| Target Description | VEGF-R2 is almost exclusively expressed on endothelial cells. It transduces the action of the well characterized pro-angiogenic vascular endothelial growth factor (VEGF-A). In pathological situations that involve neovascularization as well as enhanced vascular permeability the VEGF/VEGF-R2 signaling is responsible for activated endothelium at the tumor site. Today, VEGF-R2 is a validated target for cancer therapeutics addressing solid tumors with induced blood vessel formation. |
For Research Use Only.
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