Creative Biolabs is a professional CRO company, concentrating on providing preclinical solutions for our global clients. We provide multiple kinds of non-human primate (NHP) disease models (please click here to find more information) for you to choose from. With the advanced experimental apparatus, a professional R&D team, and the stringent Q&C system, we have accomplished many preclinical projects upon our pharmacology and pharmacodynamics (PD/PK) platform.
ALI is an acute inflammatory disease of the liver caused by various factors, such as viral infection, improper medication, food additives, excessive intake and exposure of ethanol, ingestion of toxic food, and radiation injury. Liver injury is the basis of acute liver failure, and severe or continuous liver injury eventually leads to liver failure.
A novel 3D cell culture model system has been developed by Schyschka et al. in which hepatocytes and non-parenchymal cells (NPCs) were co-cultured. This 3D cell culture model was similar to the tissue structure in the body and retained some metabolic functions. However, this in vitro model lacking the immune system cannot fully represent the liver function of the human body. Laboratory animals are considered to be useful models to investigate liver injury and its pathogenesis. Experimental animals commonly used to model ALI include rodents (mice, rats, guinea pigs, and rabbits), as well as non-rodents such as sheep, pigs, and NHPs.
A satisfying animal model of ALI should meet the following criteria: reversibility, reproducibility, development into liver failure, the presence of a treatment window, and appropriate animal size. In addition, the most important thing is to choose a species with the metabolic and physiological characteristics that are closest to humans. Therefore, NHPs are used by more and more researchers to establish ALI models.
Fig.1 Gross and histopathological changes in the cynomolgus monkey of acute liver injury (ALI). (Guo, et al., 2018)
Creative Biolabs provides the ALI model in NHPs and has accumulated much experience and scientific data about this model. Also, to better advance the preclinical study projects, we are capable of both in-life monitoring and terminal analysis including but not limited to liver function analysis (such as SOD, GSH, CAT, and MDA levels analysis), serum biochemistry, inflammatory cytokines determination, liver healing reaction assessment, immunohistochemistry, gene expression analysis (by real-time PCR), histopathological analysis of liver tissue, liver cell apoptosis detection, western blot analysis, FACS analysis, and fluorescent in situ hybridization (FISH).
If you are interested in the ALI model in NHPs or have any questions about this model, please feel free to contact us for further discussions. The scientists of Creative Biolabs will provide you with scientific solutions to any of your problems about your study project, and assist you in executing the project throughout. We are willing to work with you as your trusty CRO partner.
Equipped with rich expertise and advanced technology platforms, Creative Biolabs offers various Liver Disease Models you may be interested in:
| Liver Disease Models | |
| Non-Alcoholic Fatty Liver Disease (NAFLD) Model | Non-Alcoholic Steatohepatitis (NASH) Model |
| Primate Liver Fibrosis/Cirrhosis Model | Primate Acute Liver Injury (ALI) Model |
Reference
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