FuK peptide, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ132)
FuK is a WK2-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds.
| Overview | |
|---|---|
| Synonyms | FuK; FuK peptide |
| Source | Synthetic/Derived |
| Sequence | Gly-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-Ile-NH2 |
| Sequence Shortening | G-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-I-NH2 |
| Activity | Gram-positive bacteria; Gram-negative bacteria; Fungi; Virus; Cancer cells; Biofilm; Immunomodulation |
| Physical State | Powder |
| Purity | >98% |
| Storage | The power can be stored at 4°C for 2 years or at -20°C for 3 years. |
For Research Use Only.
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