As a world-leading service provider for antimicrobial peptide screening and drug discovery, Creative Biolabs has successfully established a panel of state-of-art technologies for exploiting candidate antimicrobial peptide targets. We have accumulated extensive experience from the accomplishment of different projects, during which we have received a lot of recognition and praise from our clients. Now, we are happy to introduce our combinatorial chemistry-based antimicrobial peptide services for developing novel peptides against bacteria.
Combinatorial chemistry methods have been broadly used for antibacterial drug discovery against various types of bacteria. The generation of the combinatorial chemistry library is a common method for rapidly screening targets of interest. Previous studies have shown that combinatorial techniques are an effective method for peptide synthesis. These approaches are capable of producing and assessing hundreds of compounds at the same time with low costs. Moreover, pilot studies have demonstrated that a large number of peptide libraries have been developed, including mRNA display peptide library, phage-display peptide library, chemically-modified peptide library, as well as the small-molecule peptide library, in the process of novel antimicrobial peptide discovery. In a recent paper, solid-phase chemistry has been applied in generating a combinatorial chemistry library from amino acids or short antimicrobial peptides. Meanwhile, several screening assays for antimicrobial peptides, such as peptide-binding assays and biochemical function assays, have also been generated to offer high-throughput strategies against various bacteria.
Fig.1 Combinatorial Chemistry-based Antimicrobial Peptide Discovery Services.
Combinatorial chemistry plays an important role in discovering novel antibiotics against different bacteria in humans. In general, it works by generating a wide variety of antimicrobial peptides libraries to identify the potential targets and further explore their drug efficacy. As a consequence, Creative Biolabs is able to provide combinatorial chemistry-based libraries for developing antibacterial drugs of your interest. The data derived from our labs have indicated that our large diverse libraries are suitable models for screening many kinds of antimicrobial peptide targets, especially for bacteria, viruses, and fungi. Meanwhile, we also provide custom combinatorial chemistry library synthesis services to meet any requirements of our clients. Notably, the mixture-based synthetic route is the most popular way in our company. For instance, a new type of antibiotic, inhibitors of bacterial peptidyl-deformylase, has been defined and evaluated by using a mixture-based combinatorial chemistry library.
Fig.2 The discovery platform for antimicrobial peptides. (Schmitt, 2019)
By continuing to grow in response to the requirements of our clients, Creative Biolabs is dedicated to exploring novel and innovative combinatorial chemistry-based antimicrobial peptide discovery assays to offer the most comprehensive, integrated portfolio of drug discovery products and solutions. If you are interested in our services, please feel free to contact us for more details.
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