Antimicrobial Peptide Products

At Creative Biolabs, we specialize in providing superior-quality antimicrobial peptide (AMP) products and customized synthesis solutions tailored for biopharmaceutical research, drug discovery, and advanced clinical applications. As a global leader in peptide engineering, our comprehensive portfolio encompasses a wide array of natural, modified, and synthetic AMPs designed to overcome modern drug resistance challenges. Backed by state-of-the-art solid-phase and liquid-phase peptide synthesis platforms, high-throughput purification technologies, and stringent quality control protocols, we empower researchers to accelerate their therapeutic pipelines from concept to validation.

Antimicrobial Peptides in Modern Biotherapeutics

Antimicrobial peptides (AMPs)—also known as host defense peptides (HDPs)—are ancient, evolutionarily conserved effector molecules of the innate immune response present across almost all living organisms. Typically short (10–50 amino acids), cationic (net charge +2 to +9), and amphipathic, AMPs possess broad-spectrum activity against Gram-positive and Gram-negative bacteria, fungi, enveloped viruses, and multidrug-resistant (MDR) pathogens. Unlike conventional small-molecule antibiotics that target specific intracellular enzymes (often leading to target mutations and rapid drug resistance), AMPs employ multifaceted lethal mechanisms that make resistance evolution significantly more difficult:

  • Membrane Permeabilization: Cationic residues (Arginine, Lysine) electrostatically bind to negatively charged outer cell surfaces (lipopolysaccharides in Gram-negative bacteria; teichoic acids in Gram-positive bacteria). Hydrophobic residues then insert into the lipid bilayer, inducing structural failure.
  • Intracellular Target Inhibition: Non-lytic AMPs cross the membrane to inhibit critical internal processes, including DNA/RNA replication, ribosomal protein synthesis, protein folding (via chaperone binding), and enzymatic metabolic pathways.
  • Anti-Biofilm & Immunomodulatory Functions: Many AMPs disperse established bacterial biofilms by downregulating quorum-sensing signaling and degrading extracellular polymeric substances (EPS). Furthermore, host defense peptides suppress excessive pro-inflammatory cytokines while attracting immune cells to the infection site.

Antimicrobial Peptides. (Creative Biolabs AI)

Biological Sources of Antimicrobial Peptides

Natural AMPs originate from diverse taxonomic kingdoms, each exhibiting distinct structural motifs optimized for host defense:

  • Mammalian & Human Origin: Prominently feature Defensins (α- and β-defensins, characterized by three intramolecular disulfide bridges) and Cathelicidins (e.g., human LL-37). These peptides exhibit potent bactericidal activity while simultaneously modulating host immune signaling.
  • Amphibian Origin: Skin secretions of amphibians are rich sources of linear α-helical peptides, such as Magainins (from Xenopus laevis) and Dermaseptins, which adopt amphipathic helices upon interaction with lipid membranes.
  • Insect Origin: Insects produce Cecropins, Melittin, and proline/glycine-rich peptides that display exceptional membrane-disrupting capabilities against severe bacterial threats.
  • Plant & Microbial Origin: Plants express cyclic or disulfide-rich Cyclotides and Thionins, whereas microorganisms produce ribosomally synthesized Lantipeptides (e.g., Nisin) containing thioether amino acids (lanthionine) that selectively bind to bacterial cell wall precursors.

Workflow of Antimicrobial Peptide Synthesis

We offer an end-to-end custom peptide synthesis workflow designed to accommodate complex sequences, novel chemical modifications, and flexible production scales.

Workflow of Antimicrobial Peptide Synthesis. (Creative Biolabs Original)

Step 1: Computational Analysis

AI-driven prediction of peptide secondary structure, net charge, amphipathic index, cytotoxicity, and hemolytic activity to optimize therapeutic window and stability.

Step 2: Chemical Synthesis

Automated Solid-Phase Peptide Synthesis (Fmoc/tBu chemistry) or Liquid-Phase Synthesis tailored for non-canonical amino acids, N/C-terminal modifications, or cyclic backbones.

Step 3: Structural Refinement

Precise regiospecific oxidation using orthogonal protecting groups to establish native disulfide bridges critical for biological activity.

Step 4: Chromatographic Separation

Preparative Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) ensuring target purity levels ranging from 80% to >98%.

Step 5: Analytical Verification

Rigorous verification via ESI-MS / MALDI-TOF mass spectrometry and analytical HPLC, accompanied by optional endotoxin content analysis and amino acid quantitative profiling.

Step 6: Lyophilization & Packaging

Aliquoting into stable, freeze-dried powders under sterile, temperature-controlled conditions for long-term storage and distribution.

Advantages of Our Products

  • Advanced Chemical Modifications: D-amino acid substitution, lipidation, PEGylation, cyclization, fluorescent tags, and non-canonical residues to maximize stability and bioactivity.
  • Guaranteed High Purity: HPLC-verified purity up to >98% ensures reproducible results without interference from synthesis byproducts.
  • Endotoxin-Controlled Production: Ultra-low endotoxin options (<0.01 EU/mg) specifically designed for sensitive mammalian cell assays and in vivo studies.
  • Flexible Scale: Scalable manufacturing options from milligram library screening to multigram pilot production.
  • Expert Technical Support: Direct support from senior peptide chemists to successfully synthesize highly hydrophobic or difficult sequences.

Frequently Asked Questions

  1. Q1: What purity level should I select for my antimicrobial peptide research?

    A1: For preliminary screening or qualitative binding assays, 85% purity is generally sufficient. However, for precise quantitative assays—such as Minimal Inhibitory Concentration (MIC), Minimal Bactericidal Concentration (MBC), cytotoxicity assays, and in vivo animal infection models—we strongly recommend a purity of >95% to ensure that trace peptide fragments or synthesis byproducts do not interfere with biological readouts.

  2. Q2: How do you handle hydrophobic or difficult-to-synthesize AMP sequences?

    A2: Many active AMPs possess high hydrophobicity or prone-to-aggregate motifs. Our chemistry team utilizes specialized synthesis strategies, including pseudo-proline dipeptides, backbone-protecting groups (isoacyl peptides), optimized coupling reagents (HATU/PyBOP), and microwave-assisted synthesis to suppress aggregation during chain elongation.

  3. Q3: Can Creative Biolabs synthesize AMPs with multiple disulfide bonds?

    A3: Yes. We have extensive expertise in selective, orthogonal cysteine protection schemes (e.g., Trt, Acm, Mob) allowing the precise, stepwise formation of up to 4 distinct disulfide bridges in complex cyclic AMP structures such as defensins, cyclotides, and toxin analogs.

  4. Q4: What are the recommended storage and reconstitution guidelines for synthetic AMPs?

    A4: Lyophilized peptides should be stored at -20°C or -80°C in a desiccated container protected from light. When reconstituting, we recommend dissolving the peptide in sterile, deoxygenated water or dilute acetic acid (for basic/cationic peptides) before diluting into working buffers. Avoid repeated freeze-thaw cycles by storing reconstituted solutions in single-use aliquots at -80°C.

Partner with Creative Biolabs to access premium antimicrobial peptide products and state-of-the-art custom synthesis services. Whether you require catalog AMP standards or tailored therapeutic peptides, contact our expert team today to support your research.

Product List

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      • Polymyxin B1, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ1)

        • Product Overview: Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.
        • Source: Bacteria
        • Molecular Formula: C56H98N16O13
        • Molecular Weight: 1203.48
        • CAS: 4135-11-9

      • LEAP-2, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ3)

        • Product Overview: LEAP-2 (Human liver expressed antimicrobial peptide-2) is a GHS-R1a antagonist, with an IC50 of 6.0 nM. LEAP-2 suppresses the orexigenic effect of ghrelin. LEAP-2 attenuates ghrelin-induced growth hormone (GH) release and reduces basal food intake. LEAP-2 exhibits antimicrobial activity against microbial model organisms. LEAP-2 can be used for the study of obesity and infection.
        • Source: Human
        • Molecular Formula: C191H316N64O57S5
        • Molecular Weight: 4581.27
        • CAS: 1683582-94-6

      • PBP10, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ4)

        • Product Overview: PBP10 is a decapeptide. PBP10 selectively binds to lipoteichoic acid (LTA), lipopolysaccharide (LPS) and phosphatidylinositol-4,5-bisphosphate (PIP2). PBP10 penetrates cell membranes and possesses bactericidal, anti-inflammatory, cell motility-inhibiting and actin assembly-regulating activities. PBP10 is applicable to relevant research on bacterial infections, microbe-induced inflammation, skin and soft tissue infections, as well as sepsis.
        • Source: Synthetic
        • Molecular Formula: C84H127N24O15+
        • Molecular Weight: 1713.06
        • CAS: 794466-43-6

      • PBP10 TFA, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ5)

        • Product Overview: PBP10 TFA is a decapeptide. PBP10 TFA selectively binds to lipoteichoic acid (LTA), lipopolysaccharide (LPS) and phosphatidylinositol-4,5-bisphosphate (PIP2). PBP10 TFA penetrates cell membranes and possesses bactericidal, anti-inflammatory, cell motility-inhibiting and actin assembly-regulating activities. PBP10 TFA is applicable to relevant research on bacterial infections, microbe-induced inflammation, skin and soft tissue infections, as well as sepsis.
        • Source: Synthetic
        • Molecular Formula: C84H127N24O15
        • Molecular Weight: 1826.07
        • CAS: 794466-43-6

      • Thiostrepton, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ6)

        • Product Overview: Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation.
        • Source: Bacteria
        • Molecular Formula: C72H85N19O18S5
        • Molecular Weight: 1664.89
        • CAS: 1393-48-2

      • Gramicidin A, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ7)

        • Product Overview: Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α).
        • Source: Bacteria
        • Molecular Formula: C99H140N20O17
        • Molecular Weight: 1882.29
        • CAS: 11029-61-1

      • Melittin TFA, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ8)

        • Product Overview: Melittin TFA is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.
        • Source: Insect
        • Molecular Formula: C131H229N39O31
        • Molecular Weight: 2960.48
        • CAS: 20449-79-0

      • Melittin, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ9)

        • Product Overview: Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.
        • Source: Insect
        • Molecular Formula: C131H229N39O31
        • Molecular Weight: 2846.46
        • CAS: 20449-79-0

      • Cecropin A, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ10)

        • Product Overview: Cecropin A is a linear 37-residue antimicrobial polypeptide, with anticancer and anti-inflammatory activity.
        • Source: Insect
        • Molecular Formula: C184H313N53O46
        • Molecular Weight: 4003.78
        • CAS: 80451-04-3

      • Alamethicin, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ11)

        • Product Overview: Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes.
        • Source: Bacteria
        • Molecular Formula: C92H150N22O25
        • Molecular Weight: 1964.34
        • CAS: 27061-78-5

      • LL-37, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ12)

        • Product Overview: LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.
        • Source: Human
        • Molecular Formula: C205H340N60O53
        • Molecular Weight: 4493.26
        • CAS: 154947-66-7

      • LL-37 acetate, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ13)

        • Product Overview: LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing.
        • Source: Human
        • Molecular Formula: C205H340N60O53
        • Molecular Weight: 4493.26 (free base)
        • CAS: 154947-66-7

      • LL-37 TFA, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ14)

        • Product Overview: LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing.
        • Source: Human
        • Molecular Formula: C205H340N60O53
        • Molecular Weight: 4493.26 (free base)
        • CAS: 154947-66-7

      • LL-37 amide, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ15)

        • Product Overview: LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing.
        • Source: Human
        • Molecular Formula: C205H341N61O52
        • Molecular Weight: 4492.28
        • CAS: 597562-32-8

      • LL-37 amide TFA, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ16)

        • Product Overview: LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED99=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing.
        • Source: Human
        • Molecular Weight: 4492.28 (free base)

      • Protegrin-1, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ20)

        • Product Overview: Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NFκB, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 µM. Protegrin-1 has antiviral activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections.
        • Source: Porcine
        • Molecular Formula: C88H147N37O19S4
        • Molecular Weight: 2155.61
        • CAS: 168831-77-4

      • Daptomycin, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ23)

        • Product Overview: Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
        • Source: Bacteria
        • Molecular Formula: C72H101N17O26
        • Molecular Weight: 1620.67
        • CAS: 103060-53-3

      • Nisin, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ24)

        • Product Overview: Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity.
        • Source: Bacteria
        • Molecular Formula: C143H230N42O37S7
        • Molecular Weight: 3354.07
        • CAS: 1414-45-5

      • Larazotide, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ25)

        • Product Overview: Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection.
        • Source: Synthetic
        • Molecular Formula: C32H55N9O10
        • Molecular Weight: 725.83
        • CAS: 258818-34-7

      • Larazotide acetate, Antimicrobial Peptide (AMP) (CAT#: BMWJ-0826-WJ26)

        • Product Overview: Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.
        • Source: Synthetic
        • Molecular Formula: C34H59N9O12
        • Molecular Weight: 785.89
        • CAS: 881851-50-9

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